| Pair Name | Hesperetin, Sorafenib | ||
| Phytochemical Name | Hesperetin (PubChem CID: 72281 ) | ||
| Anticancer drug Name | Sorafenib (PubChem CID: 216239 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Drug Name | Sorafenib |
| Adverse Reactions | Facial red macules, dry skin, acne, alveolitis. This was inferred hot nature anticancer drug. |
| Recommendations | Cold: Ilex hainanensis; Mangifera indica; Camellia sinensis; Sophora flavescens; Eriobotrya japonica; Citrus aurantium; |
| Reference | Malignant tumors in the era of immunotherapy based on traditional Chinese medicine's "cold and hot theory" Construction of integrated traditional Chinese and Western medicine treatment paradigm[J]. Modern Journal of Integrated Traditional Chinese and Western Medicine,2023,32(12):1712-1716. DOI:10.3969/j.issn.1008-8849.2023.12.022. ref_link |
| Pair Name | Hesperetin, Sorafenib | |||
| Disease Info | [ICD-11: 2C12] | Hepatocellular carcinoma | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Down-regulation | Expression | DNM1L | hsa10059 |
| In Vivo Model | Swiss albino mice were orally administered sorafenib (100 mg/kg) alone or in combination with hesperetin (50 mg/kg) over 21 days. | |||
| Result | Hesperetin exhibits potential as an adjunct to sorafenib, mitigating its side effects by attenuating its toxicity, enhancing efficacy, and potentially reducing the occurrence of sorafenib-induced resistance through the downregulation of hepatocyte growth factor levels. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Protective role of hesperetin in sorafenib-induced hepato- and neurotoxicity in mice via modulating apoptotic pathways and mitochondrial reprogramming. Life Sci. 2024 Jan 1;336:122295. doi: 10.1016/j.lfs.2023.122295. | Click |
